Editor’s Be aware: This text is a reprint. It was initially printed January 28, 2018.
One in Four People over the age of 45 is on a statin drug to decrease their ldl cholesterol. Are these medicine actually as unhealthy as a few of the proof suggests — or may they be even worse than suspected? Stephanie Seneff, Ph.D., is a senior analysis scientist at Massachusetts Institute of Expertise (MIT) whom I’ve interviewed on various events.
She’s an absolute treasure trove of helpful well being info. Right here, we talk about statin medicine, that are additionally featured in her fictional e book, “Cindy and Erica’s Obsession to Remedy the Healthcare Disaster in America,” for which I wrote the foreword. The story, whereas fictional, is predicated on Seneff’s personal life and keenness for science, and delves into autism, Alzheimer’s, statins, vaccines, glyphosate and extra.
On this interview, we concentrate on one other e book, “The Darkish Facet of Statins: Plus, the Marvel of Ldl cholesterol,”1 the final one written by Dr. Duane Graveline, who himself was a sufferer of statin unwanted side effects and died from issues associated to statin use. Seneff’s husband was additionally severely affected by statins, which triggered her scientific exploration into these standard medicine.
“He actually modified my profession by getting sick,” she says. “He was recognized with coronary heart illness 10 years in the past and placed on a high-dose statin — 4 occasions the traditional dosage. The physician stated, ‘It’s important to take this for the remainder of your life. Should you do not, I’ll not be your physician.’ And he instantly began affected by unwanted side effects — muscle pains and weak spot; even the street rage and behavioral modifications.
I simply knew this drug wasn’t working and I began researching statins … In actual fact, I began doing it as a part of my work at MIT. I began analyzing statin unwanted side effects and discovering all types of horrible issues. He received off them after a 12 months. He slowly tapered it down and I am completely happy to say he is statin free and doing nice at this level, 10 years later. His docs carry on reminding him [to go back on a statin] and he retains on telling them no, politely.”
How Research Overestimate Statin Advantages
As famous by Seneff, it’s fairly straightforward to overestimate the advantages of statins by complicated individuals with absolute and relative danger. It is a statistical trick used fairly incessantly to show drug effectiveness. Seneff explains:
“They do a research by which absolutely the danger could be very uncommon. As an instance 2 % of the inhabitants is definitely anticipated to have no matter it’s they’re monitoring, like, say, a coronary heart assault. They then look over a time frame and discover that 2 % of the management group has the incidence [they’re looking for, in this case a heart attack] and the therapy group has, to illustrate, 1.5 % as a substitute of two %.
That is a 0.5 % decreased danger from [the individual’s] standpoint, however from their standpoint, it’s a 25 % improved efficiency as a result of it is 0.5 out of two — one-quarter of the relative danger has been taken away. Due to this fact, it is a 25 % enchancment, which sounds significantly better than 0.5 %.”
Statins Supply Poor Protection Towards Coronary heart Illness
Sadly, whereas statins might lower the frequency of delicate coronary heart assaults, they won’t essentially decrease your danger of coronary heart illness or demise from a significant coronary heart assault due to the harm they do to your muscle tissue, together with your coronary heart muscle. On a aspect word, statins’ means to decrease the danger of minor coronary heart assaults is probably going associated to their means to decrease C-reactive protein, way more so than the reducing of ldl cholesterol.
Nevertheless, based on Graveline, you solely want one-tenth of the dosage, say 2 milligrams (mg) fairly than 20 mg to get this anti-inflammatory profit, and there are far safer and simpler methods to decrease irritation than taking a statin, even at a low dosage. As Seneff says, “You are buying and selling coronary heart assault for coronary heart failure, and I believe a coronary heart assault is most well-liked over coronary heart failure.” There are three main the reason why statins fail to lower the speed of demise from coronary heart illness:
1. Statins decrease your ldl cholesterol, which is a vital precursor for a lot of of your steroid hormones, together with progesterone, testosterone, aldosterone, cortisol and vitamin D. Ldl cholesterol sulfate (produced once you expose your pores and skin to the solar) enters cell membranes and helps construct structured water that protects towards oxidative harm. Ldl cholesterol can be wanted to create DHEA sulfate.
2. In addition they deplete your physique of Coenzyme Q10 (CoQ10), which is required for muscle well being, and lowers your ranges of vitamin K2 and HMG co-enzyme A reductase, the latter of which is an enzyme your liver makes use of to make ketones. So, if you happen to’re on a statin drug, you could have dramatically impaired ketone manufacturing, even if you happen to’re fasting.
3. Statins additionally decrease dolichol, which Graveline believed is simply as vital as CoQ10. Not solely does dolichol play an vital position in mitochondrial perform, it is usually liable for the method of placing sugar chains on prime of glycosylated proteins. That is vital as a result of these so-called glycosaminoglycans assist preserve the barrier perform within the cell and regulate the uptake of vitamins.
In sensible phrases, which means that your muscle cells (together with your coronary heart cells), which require plenty of power, get closely impacted by statins. One aspect impact from lack of dolichol is Sort 2 diabetes, and statins have certainly been discovered to trigger drug-induced diabetes. Dolichol additionally fixes DNA errors. CoQ10, a strong antioxidant, additionally helps, and each of those DNA “restore masters” are depleted by statins.
Statins Make You Age Sooner
Opposite to standard perception, excessive ldl cholesterol just isn’t a main danger issue for coronary heart illness. It’s truly a significant nutrient wanted for well being that shouldn’t be artificially and indiscriminately suppressed.
“That is completely true,” Seneff says. “When my husband was prescribed a statin, I knew ldl cholesterol was vitally vital to the physique and I knew there was excessive concentrations within the mind.
Two % of the physique’s weight and 25 % of the physique’s ldl cholesterol within the mind. So, you do not wish to mess with shedding ldl cholesterol in your mind. In fact, statin unwanted side effects embody a number of cognitive points and that was one of many issues that confronted Graveline.
He suffered one thing known as transient international amnesia after taking statins for about three months. The docs stated, ‘No means the statin might be inflicting that,’ however he wished to [stop taking] it anyway … A 12 months later, the physician stated, ‘Properly, the statin did not trigger it, so you need to return on the statin since you nonetheless have excessive ldl cholesterol.’
He went again on [the statin] and shortly thereafter he had one other episode of transient international amnesia. From that time on, he stopped taking the statin.
Then he turned obsessed and wrote a number of books on statins … [H]e died of an ALS-like situation, which he suspected the statins had contributed towards … [I]n the e book he says, ‘Statins make you get older quicker.’ And I believe that is an excellent method to describe them.
They provide you all of the stuff you get once you become older, quicker. And because you by no means received outdated earlier than, you do not know how briskly you are alleged to get outdated, so that you simply assume, ‘Properly, I am getting outdated. That is simply the best way it’s.’ And it is not. It needs to be a lot, a lot slower … So, everybody will get duped. Every individual individually will get outdated quick and would not understand that is taking place to them due to the statin.”
Defend Your Coronary heart: Watch out for Cellphone Radiation
Two components that may have a major affect in your coronary heart well being and danger of coronary heart illness are publicity to glyphosate-containing pesticides and electromagnetic fields (EMFs). Seneff touches on each of those points on this interview, noting that every additionally tends to worsen the consequences of the opposite. “I believe glyphosate messes up your pure electrical system, which makes you way more vulnerable to EMFs,” she says.
Contemplating the proof, I firmly imagine extreme publicity to microwave radiation from cellphones and different wi-fi applied sciences are a hidden and fully ignored contributor to coronary heart illness. Whereas evaluating research exhibiting you may radically cut back organic microwave harm utilizing calcium channel blockers, Martin Pall, Ph.D., found a beforehand unknown mechanism of organic hurt from microwaves emitted by wi-fi applied sciences.2
Embedded in your cell membranes are voltage gated calcium channels (VGCCs), that are activated by microwaves. When that occurs, they open up, permitting an enormous inflow of intracellular calcium, which in flip stimulates the discharge of nitric oxide (NO).
Inside your cell and mitochondria, this NO combines with superoxide to type peroxynitrite. Not solely do peroxynitrites trigger oxidative harm, in addition they create hydroxyl free radicals, that are profoundly damaging and trigger mitochondrial dysfunction.
One of many tissues with the best density of VGCCs is the pacemaker in your coronary heart. What the analysis tells us is that extreme microwave publicity could be a direct contributor to situations comparable to cardiac arrhythmias.3 In response to Seneff, EMFs additionally contribute to arterial calcification (blocked arteries). So, if you happen to care about your coronary heart well being, and/or already battle with coronary heart issues, you’ll wish to ensure you:
- Keep away from carrying your cellphone in a pocket close to your coronary heart
- Keep away from utilizing moveable computer systems and tablets
- Flip off your cellphone at night time, as even if you’re not speaking it may harm you as much as 30 toes away until it’s in airplane mode with Bluetooth and site providers turned off
- Flip off your Wi-Fi at night time (ideally within the day additionally)
- Most significantly, flip off the electrical energy to your bed room on the circuit breaker every night time. This usually works for many bedrooms until you could have a room or rooms adjoining to your bed room, by which case you may have to shut that off too. This may radically decrease electrical and magnetic fields whilst you sleep. Should you want a clock you should utilize a battery-operated one and even higher a speaking clock with no gentle that may be picked up on Amazon
Stunning Glyphosate Statistics
Each glyphosate and EMF publicity have dramatically elevated in latest a long time. Between 1974 (the 12 months glyphosate entered the U.S. market and simply over twenty years earlier than GE crops have been launched) and 2014, glyphosate use within the U.S. elevated greater than 250-fold. Globally, glyphosate use rose practically fifteenfold since 1996, two years after the primary GE crops hit the market.4
Latest analysis reveals that whereas few people had detectable ranges of glyphosate of their urine in 1993, by 2016, 70% of them had it.5 Total, the prevalence of human publicity to glyphosate elevated by 500% through the research interval (1993 to 2016), whereas precise ranges of the chemical in individuals’s our bodies elevated by an astounding 1,208%.
Glyphosate Will increase Allergenic Potential of Proteins
Seneff has performed a number of analysis on glyphosate, teasing out various mechanisms by which it causes organic hurt. A lot of this was mentioned in “Roundup Herbicide Could Be Most Necessary Consider Growth of Persistent Illness.”
Extra not too long ago, Seneff and her analysis accomplice, Anthony Samsel, a analysis scientist and environmental and public well being marketing consultant, have discovered a major quantity of circumstantial proof suggesting the chemical takes the place of glycine (an amino acid) in proteins, thereby impairing trypsin’s perform, which is to digest proteins.
This will increase the proteins’ allergenic potential. Glyphosate additionally causes leaky intestine, permitting undigested proteins entry to your basic blood circulation. The top result’s autoimmune illness, as your immune cells go into overdrive. “We have now an epidemic in all types of various autoimmune ailments and meals allergy symptoms, and I believe all of that traces again to glyphosate,” she says.
The “gly” in glyphosate truly stands for “glycine,” which is likely one of the most typical and likewise the smallest amino acid. So, glyphosate is mainly a glycine molecule with a aspect chain hooked up to the nitrogen atom, and although it’s a modified glycine molecule, it’s nonetheless glycine. That is why it may substitute the common amino acid glycine in your system. Sadly, it’s now poisonous. Seneff explains:
“Sure proteins have sure glycines that completely must be glycine to ensure that them to work correctly. instance is myosin. Myosin within the muscle tissue [allow for] muscle contraction. It is a actually vital protein within the muscle tissue for motion. It has a glycine at place 699 within the amino acid sequence. Should you change that glycine into alanine, which is to say you add one additional methyl group, it ruins the protein.
It solely has 1 % capability to contract. It loses 99 % of its capability to contract. Actually superb. So, if you happen to put glyphosate as a substitute of glycine, you are going to have not less than as unhealthy an impact as you’ll with alanine, and doubtless worse. It is going to cripple the protein and possibly that is the way you get power fatigue syndrome.”
Different Antagonistic Well being Results of Glyphosate
Collagen additionally incorporates massive quantities of glycine, and we’ve an epidemic of joint ache, again ache, knee and hip ache. These too could be the results of glyphosate publicity. Glyphosate additionally impairs well being by inflicting imbalance in your intestine microbiome, and by weakening your immune system. Seneff explains:
“The neutrophils are unable to do their job after which the tryptophan will get squirreled away contained in the macrophages as kynurenine, [which] then will get taken over to the mind, inflicting all types of bother within the mind.
So, there’s this complete sophisticated factor that is occurring between the mind and the intestine — the gut-brain axis communication system — with the microbes being tousled by the glyphosate, the intestine being leaky, and the leaky intestine barrier introducing a leaky mind barrier.
So, the boundaries are all leaky. The placental barrier is leaky too, so the placenta will get in bother throughout being pregnant. All these items that is taking place due to glyphosate. It’s such a cascade.”
Glyphosate additionally depletes meals of tryptophan by impairing the shikimate pathway within the plant. Because of this, meals is turning into more and more tryptophan depleted, resulting in widespread deficiency. Finally, you will get right into a scenario the place the tryptophan will get completely depleted, and when your liver would not get sufficient, it can not make sufficient N-arachidonoyl dopamine (NADA) — one of the crucial vital signaling molecules in your physique — as a result of NADA will depend on tryptophan.
Downstream, you might also find yourself with serotonin and melatonin deficiency within the mind, which might result in sleep problems, melancholy and violent or suicidal habits. Apart from tryptophan, disruption of the shikimate pathway additionally decreases all the different fragrant amino acids, together with tyrosine and phenylalanine, together with all of their derivatives, which embody dopamine and melanin and folate.
Dietary supplements Advisable for Statin Customers
As talked about, statin medicine deplete your physique of various vital vitamins. Because of this, Graveline recommends taking the next dietary supplements if you happen to’re on a statin drug:
Ubiquinol, the lowered model of CoQ10.
Folate — Keep away from folic acid, the artificial model of folate, as it’s oxidized and can expend a number of antioxidant capability in your liver to show it into folate. Furthermore, you probably have been uncovered to glyphosate, your physique’s means to do that will probably be impaired. complement type is 5-methyltetrahydrofolate (5-MTHF).
Vitamin C — Your finest guess right here is to easily eat vitamin C-rich meals, and solely take a vitamin C complement if you happen to’re feeling in poor health. The liposomal model of vitamin C could be very efficient. I usually advocate taking it each hour till you’re feeling higher. Liposomal vitamin C can also assist abort an allergic response when taken in excessive quantities.
Selenium — Statins wreak havoc with selenoproteins, so a selenium complement is advisable. In actual fact, most individuals have to take supplemental selenium.
Lecithin — I am not a giant fan of lecithin and I’d recommend merely consuming one complete natural, pastured egg per day as a substitute. Lecithin is phosphatidylcholine, which eggs include loads of. If choosing a complement, I like to recommend utilizing a liposomal type. Additionally be sure it’s not comprised of genetically engineered soy. A safer various is natural sunflower lecithin.
Animal-based omega-Three fat — Best sources embody small fatty fish comparable to sardines and anchovies and salmon roe. Ideally, test your omega-Three index to ensure you’re in a wholesome vary.
D-Ribose, as statins intrude with D-Ribose processing.
Magnesium — Most individuals are poor in magnesium, however if you happen to’re on a statin, you could be at even higher danger. Having low magnesium additionally raises your danger of struggling adversarial results from EMF, as magnesium is a pure calcium channel blocker. If you take excessive sufficient doses of magnesium, you truly decrease your danger for growing harm from EMFs.
Alpha lipoic acid — It is a sulfur-containing molecule which can be a part of its profit.
Vitamin K2 — Statins block the K2 pathway and impair vitamin K2 absorption, and K2 is vital for the prevention of arterial calcification, because it helps shuttle calcium out of soppy tissues into your enamel and bones, the place it belongs.
Pyrroloquinoline quinone, extra generally often called PQQ. Much like CoQ10, PQQ helps enhance mitochondrial perform.
Possibilities Are You Don’t Want a Statin
That statins have proliferated the best way they’ve is an affidavit to the facility of selling, corruption and company greed, as a result of the percentages are very excessive — higher than 100 to 1 — that if you happen to’re taking a statin, you do not actually need it. The one subgroup of individuals I imagine may profit from it are these born with a genetic defect known as familial hypercholesterolemia, as this makes them proof against conventional measures of normalizing ldl cholesterol.
Much more importantly, ldl cholesterol just isn’t the reason for coronary heart illness. Coronary heart illness is essentially brought on by irritation, as a number of specialists have defined intimately, together with Dr. Ron Rosedale, Dr. Uffe Ravnskov, Dr. Stephen Sinatra and Stephanie Seneff. Elevated ldl cholesterol is your physique’s pure response to irritation. It’s wrongly blamed as a result of it’s discovered on the “scene of the crime,” but it surely’s not the legal.
In case your doctor is urging you to test your complete ldl cholesterol, then you need to know that this check will let you know just about nothing about your danger of coronary heart illness until it’s 330 or increased. HDL proportion is a much more potent indicator for coronary heart illness danger. Listed below are the 2 ratios you need to take note of:
- HDL/Whole Ldl cholesterol Ratio — Ought to ideally be above 24%. If beneath 10%, you could have a considerably elevated danger for coronary heart illness.
- Triglyceride/HDL Ratio — Must be beneath 2%.
Bear in mind, your physique wants ldl cholesterol. It will be significant within the manufacturing of cell membranes, hormones, vitamin D and bile acids that enable you to to digest fats. Ldl cholesterol additionally helps your mind type recollections and is important to your neurological perform. There may be additionally sturdy proof that having too little ldl cholesterol truly will increase your danger for most cancers, reminiscence loss, Parkinson’s illness, hormonal imbalances, stroke, melancholy, suicide and violent habits.
So, please, assume lengthy and exhausting earlier than filling a prescription for a statin drug, and start by implementing wholesome way of life methods as a substitute. You could find a protracted listing of articles detailing coronary heart wholesome methods right here.